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First genetic risk factor for erectile dysfunction identified

By: Kaiser Permanente
Source: https://www.sciencedaily.com
web site: https://www.sciencedaily.com/releases/2018/10/181008183357.htm

For the first time, a team of researchers has found a specific place in the human genome that raises a person's risk of erectile dysfunction. The discovery is a significant advancement in the understanding of the genetics underlying erectile dysfunction. The study, "Genetic variation in the SIM1 locus is associated with erectile dysfunction," will be published the week of October 8 in the journal Proceedings of the National Academy of Sciences.

Erectile dysfunction, the inability to obtain and maintain an erection sufficient for sexual activity, is a common and costly condition of men of primarily middle and older ages. The disease is linked to many causes, such as neurological, hormonal and vascular factors.

Therapies based on these factors exist, but many men don't respond to them. Genetics also are suspected as a factor in about one-third of erectile dysfunction cases, but researchers have failed to make an association with any specific genomic locations until now.45

The new study found that variations in a specific place in the genome -- called a genetic locus -- near the SIM1 gene are significantly associated with an increased risk of erectile dysfunction. The researchers ruled out that the risk was due to other known risk factors for erectile dysfunction, such as body mass index, or differences in how men describe their erectile dysfunction. The study also demonstrated a biological role for the genetic location in regulating sexual function, strongly suggesting that these variations can cause erectile dysfunction.

"Identifying this SIM1 locus as a risk factor for erectile dysfunction is a big deal because it provides the long sought-after proof that there is a genetic component to the disease," said the study's lead author, Eric Jorgenson, PhD, a research scientist at Kaiser Permanente Northern California's Division of Research. "Identifying the first genetic risk factor for erectile dysfunction is an exciting discovery because it opens the door for investigations into new, genetic-based therapies."

The researchers conducted a genome-wide association study in two large and diverse cohorts to investigate genetic contributors to the risk of erectile dysfunction. The first cohort included 36,648 men from the Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort, which is part of the Kaiser Permanente Research Program on Genes, Environment and Health, a research program affiliated with the Kaiser Permanente Research Bank. The Research Bank supports external and internal investigation into a variety of health conditions and diseases and includes biospecimens from more than 320,000 consenting Kaiser Permanente members, as well as linked genetic, environmental and health data.

The GERA cohort included male members of Kaiser Permanente who completed a survey on their condition, had a clinical diagnosis of erectile dysfunction based on their electronic health records, and had used drugs or other erectile dysfunction treatments. The findings in the GERA cohort were then verified in a cohort of 222,358 men from the U.K. Biobank.

Erectile dysfunction is red flag for silent early cardiovascular disease

By: SAGE
Source: Science Daily
web site: https://www.sciencedaily.com/releases/2017/12/171215121016.htm

Despite decades long prevention and treatment efforts, cardiovascular (CV) disease continues to be the leading cause of death worldwide. Early detection of CV disease can allow for interventions to prevent heart attack and stroke, including smoking cessation, medications such as a statins, blood pressure control, weight management, exercise, and improved diet. A new study published online first today in the journal Vascular Medicine, focuses on a novel risk factor for cardiovascular disease that rarely receives attention -- erectile dysfunction.

In addition to being an important health and quality of life issue for men, erectile dysfunction has long been associated with CV disease. Risk factors for erectile dysfunction and CV disease are similar -- including older age, smoking, obesity, and diabetes, among others. In addition, multiple overlapping mechanisms lead to the development of both erectile dysfunction and CV disease.

In the article entitled "The relationship of erectile dysfunction and subclinical cardiovascular disease: A systematic review and meta-analysis," Drs. Chukwuemeka Osondu (Baptist Health South Florida), Bryan Vo (Florida International University), Ehimen Aneni (Mount Sinai Medical Center), and colleagues sought to establish erectile dysfunction as a simple and effective marker of underlying subclinical CV disease. They hypothesized that "measures of erectile dysfunction could be a simple effective CV disease risk stratification tool, particularly in young men who are less likely to undergo aggressive TorontoEffectiveErectileDysfunctioClinicCVD risk assessment and management."

The authors conducted a systematic review and meta-analysis of 28 studies that examined the link between erectile dysfunction and measures of early CV disease. They report a significant association of erectile dysfunction with impaired endothelial function (measured by brachial flow-mediated dilation using ultrasound), a marker of the ability of blood vessels to relax that is an early event in vascular disease development. In addition, the authors report that erectile dysfunction was associated with increased carotid intimal medial thickness (carotid IMT), an early manifestation of atherosclerosis. The results for the association of erectile dysfunction and coronary artery calcium scoring were inconclusive due to small number of studies with limited sample size. The authors identify this as an area in need of future study.

As explained by the authors, "Our study findings indicate that [young] men [with erectile dysfunction] are at greater risk of having identifiable subclinical CV disease and will benefit from an active CV disease work-up...Our study supports a more aggressive CV disease risk assessment and management for persons with erectile dysfunction, including young men who may otherwise be categorized as low risk due to their young ages."

In an accompanying editorial, Drs. Naomi Hamburg and Matt Kluge (Boston University) agree: "The presence of erectile dysfunction portends a higher risk of future cardiovascular events, particularly in intermediate risk men, and may serve as an opportunity for intensification of cardiovascular risk prevention strategies." They add "The findings add to the growing evidence supporting additional trials to determine the clinical impact of erectile dysfunction screening and the appropriate cardiovasculardirected evaluation and treatment of men with erectile dysfunction."

Erectile Dysfunction Much More Common Among Young Men Than Previously Thought

By: Written by Joseph Nordqvist
Source: Medical News Today
web site: https://www.medicalnewstoday.com/articles/261673

According to a new analysis, published in The Journal of Sexual Medicine, the number of young men suffering from erectile dysfunction may be much higher than previously thought.

Erectile dysfunction, also known as impotence or ED, occurs when a man is unable to sustain an erection which is sufficient for sexual intercourse.

Prime treatment options for ED are the drugs Viagra, Cialis, and Levitra. However, according to a study presented at the 28th Annual EAU Congress, despite the high prevalence of ED, most patients receive no treatment.

Previous research, led by physician-scientists at NewYork-Presbyterian Hospital/Weill Cornell Medical Center, revealed that 65 percent of men with ED are unable to have an orgasm and 58 percent have problems with ejaculation.

Most erectile dysfunction (ED) complaints are among men above the age of 40 and prevalence increases with age.43

However, the risk and prevalence of erectile dysfunction among young people hasn’t been looked at very thoroughly.

Researchers have identified that one quarter of men seeking help for ED are younger than 40. Half of these men reported severe ED.

Paolo Capogrosso, MD, of the University Vita-Salute San Raffaele, in Milan, Italy, and his team assessed a total of 439 men who were seeking medical help because of ED at an academic outpatient clinic between January 2010 and June 2012.

114 (26 percent) of the men were under the age of 40. The younger patients tended to have a lower body mass index, more testosterone in their blood and a lower rate of concomitant medical conditions.

Smoking and illicit drug use was more common in young men and they were also more likely to experience premature ejaculation.

The rate of severe erectile dysfunction was higher among the younger patients compared to the older ones (48.8 percent versus 40 percent respectively).

Dr. Capogrosso said that the study showed the importance of thorough physical examinations among all men with erectile dysfunction, regardless of their age.

He added:

“These findings, taken together with those of other studies showing the importance of erectile dysfunction as a potential “sentinel marker” of major diseases, outline the importance of taking a comprehensive medical and sexual history and to perform a thorough physical examination in all men with erectile dysfunction, irrespective of their age.”

Irwin Goldstein, editor-in-chief of The Journal of Sexual Medicine, concluded:

“Erectile function, in general, is a marker for overall cardiovascular function – this is the first research showing evidence of severe erectile dysfunction in a population of men 40 years of age or younger. Clinically, when younger patients have presented with erectile dysfunction, we have in the past had a bias that their ED was primarily psychologic-based and vascular testing was not needed.

We now need to consider regularly assessing the integrity of arterial inflow in young patients – identifying arterial pathology in such patients may be very relevant to their overall long-term health.”

Is it safe to buy erectile dysfunction pills online?

By: Medically reviewed by Janet Brito, Ph.D., LCSW, CST — Written by Jessica Caporuscio, Pharm.D. on August 4, 2020
Source: Medical News Today
web site: https://www.medicalnewstoday.com/articles/ed-pills-online#buying-online

Some companies offer erectile dysfunction (ED) pills online without the need for a prescription. The Food and Drug Administration (FDA) do not regulate these products, so they may not be safe. Some might contain harmful ingredients that the manufacturers do not list on the label.

According to the FDA, the number of ED products available online is increasing. However, people must be vigilant and avoid unregulated ED remedies, including those that manufacturers claim to be “natural supplements.”

This article will look at some drugs that help with ED, the risks associated with buying them online, and where to get ED pills safely. It will also discuss some other ways of treating ED.
Pills for ED
It is much safer to purchase ED pills from a licensed pharmacy than online.

Phosphodiesterase-5 (PDE-5) inhibitors are medications that males can use to help treat ED. These drugs prolong erections by blocking the action of phosphodiesterase enzyme, which triggers the end of an erection.

The FDA have approved the use of four PDE-5 inhibitors for ED:
Drug name Dose
avanafil (Stendra) 50 milligrams (mg), 100 mg, 200 mg
sildenafil (Viagra) 25 mg, 50 mg, 100 mg
tadalafil (Cialis) 2.5 mg, 5 mg, 10 mg, 20 mg
vardenafil (Levitra) 5 mg, 10 mg, 20 mg

Depending on the efficacy and side effects a male may experience while taking any of these drugs, doctors may recommend a different dosage.

PDE-5 inhibitors are also available on prescription in other formats. For example, alprostadil (Muse) is a suppository that males can insert into the urethra of the penis. The same medication is also available in an injectable form called Caverject.
Is it safe to buy ED pills online?44

People should not buy ED pills online unless they have a prescription from a doctor and are purchasing them from a reputable online pharmacy. The FDA do not regulate online ED products to check that they are safe.

According to an FDA report, around one-third of ED supplements they assessed contained other prescription drugs or other unlisted ingredients. Six out of 17 products contained sildenafil or another PDE-5 inhibitor.

This means that ED products available online could contain harmful substances or high amounts of drugs that consumers are not aware of. Taking high doses of PDE-5 inhibitors such as vardenafil can cause:

back pain
muscle pain
abnormal vision

Since 2004, the FDA have identified the following products as unsafe:

Actra-Rx
Hero
Libidus
Naustra
NaturalUp
Neophase
Vigor-25
Xiadafil VIP
4EVERON

Causes of erectile dysfunction

By: Medically reviewed by Daniel Murrell, M.D. — Written by Rachel Nall,
Source: Medical News Today.
web site: https://www.medicalnewstoday.com/articles/321795#causes-of-erectile-dysfunction

A man can experience ED for a number of reasons. Men of all ages can experience the condition. While people associate getting older with ED, this does not have to be the case.

Certain conditions that affect blood flow can cause ED, including:

diabetes
high blood pressure
history of alcohol and tobacco use
history of brain or spinal cord injuries
history of radiation to the testicles
multiple sclerosis
Parkinson’s disease
bladder or prostate surgery
stroke

Taking certain medications is also associated with ED. These include antidepressants, blood pressure-lowering medicines, and medications for pain.

In addition, mental health disorders, anxiety, or a dysfunctional relationship with a partner can all contribute to ED in men.42
Outlook

ED is a common and often treatable condition affecting men. Although doctors have not conducted specific research studies related to how dehydration specifically affects ED, there are other studies and literature that can establish a link.

However, dehydration is usually a temporary condition and not typically the sole contributor to long-term ED. If a man is consistently having trouble getting or maintaining an erection, he should talk to his doctor for a diagnosis.
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