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Viagra (sildenafil)

By: Medically reviewed by Alex Brewer, PharmD, MBA on May 1, 2020 — Written by Helen Marshall, BPharm, MRPharmS
Source: Medical News Today
web site: https://www.medicalnewstoday.com/articles/viagra

What is Viagra?

Viagra is a brand-name prescription drug that’s approved to treat erectile dysfunction (ED). With ED, you’re unable to have or maintain an erection. Viagra is approved for this use in males ages 18 years and older.

Viagra contains the drug sildenafil. It belongs to a class of drugs called phosphodiesterase type 5 (PDE5) inhibitors. (A class of drugs is a group of medications that act in a similar way.) Viagra works by increasing blood flow to your penis, which helps you have and keep an erection. But this drug only works if you’re sexually aroused.26

Viagra comes as tablets that are taken by mouth. In most cases, it should be taken about an hour before sexual activity, but it can be taken 30 minutes to 4 hours beforehand. Viagra is available in three strengths: 25 mg, 50 mg, and 100 mg.
Does Viagra work to treat ED?

Yes, it does. In several clinical studies, Viagra was effective in treating ED. In these studies, men who used the drug had an improved ability to have and keep erections that allowed for successful sex.

Across the studies, between 43% and 83% of men who took Viagra had improved erections. (These rates varied depending on the cause of their ED and the dosage of Viagra being used.) In comparison, improved erections occurred in 10% to 24% of men who took a placebo (no active drug).

To learn more about Viagra’s effectiveness, see the “Viagra uses” section below.
Viagra generic

Generic versions of Viagra are available. A generic drug is an exact copy of the active drug in a brand-name medication. The generic is considered to be as safe and effective as the original drug. Generics tend to cost less than brand-name drugs.

Viagra contains the active drug sildenafil.
Viagra side effects

Viagra can cause mild or serious side effects. The following lists contain some of the key side effects that may occur while taking Viagra. These lists don’t include all possible side effects.

For more information on the possible side effects of Viagra, talk with your doctor or pharmacist. They can give you tips on how to deal with any side effects that may be bothersome.

Note: The Food and Drug Administration (FDA) tracks side effects of drugs it has approved. If you would like to report to the FDA a side effect you’ve had with Viagra, you can do so through MedWatch.
Mild side effects

Mild side effects of Viagra can include:*

headache
flushing
indigestion
mild and temporary vision changes, such as a blue tinge in your vision, blurred vision, and sensitivity to light
nasal congestion (stuffy nose)
back pain
muscle pain
nausea
dizziness
rash

Most of these side effects may go away within a few days or a couple of weeks. But if they become more severe or don’t go away, talk with your doctor or pharmacist.

* This is a partial list of mild side effects from Viagra. To learn about other mild side effects, talk with your doctor or pharmacist, or view the drug’s patient information.
Serious side effects

Serious side effects from Viagra aren’t common, but they can occur. Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life threatening or if you think you’re having a medical emergency.

Serious side effects and their symptoms can include:

Non-arteritic anterior ischemic optic neuropathy (NAION), which is an eye condition that causes damage to your optic nerve. Symptoms can include:
sudden decrease in vision in one or both of your eyes
sudden loss of vision in one or both of your eyes
Sudden decrease or loss of hearing. This condition may also involve other symptoms, such as:
tinnitus (ringing or buzzing in your ears)
dizziness

Other serious side effects, which are explained in more detail below in “Side effect details,” include:

allergic reaction
priapism (long-lasting and sometimes painful erection)
low blood pressure, if Viagra is taken with certain other medications
cardiovascular problems, such as heart attack, irregular heartbeat, or stroke, all of which occur mainly in people with heart disease

Side effect details

You may wonder how often certain side effects occur with this drug. Here’s some detail on several of the side effects this drug may cause.
Allergic reaction

As with most drugs, some people can have an allergic reaction after taking Viagra. In clinical studies, less than 2% of people who took Viagra had an allergic reaction. It’s not known how often allergic reactions occurred in people who took a placebo (no active drug).

Symptoms of a mild allergic reaction can include:

skin rash
itchiness
flushing (warmth and redness in your skin)

A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include:

swelling under your skin, typically in your eyelids, lips, hands, or feet
swelling of your tongue, mouth, or throat
trouble breathing

Call your doctor right away if you have a severe allergic reaction to Viagra. But call 911 if your symptoms feel life threatening or if you think you’re having a medical emergency.
Priapism

Rarely, Viagra can cause priapism, which is a long-lasting and sometimes painful erection. But it’s not known how often priapism occurs in men who take Viagra.

Priapism is a medical emergency that needs to be treated right away. If it’s not treated, the condition can damage the tissues in your penis and cause irreversible erectile dysfunction (ED).

If you have an erection that lasts longer than 4 hours, go to the nearest emergency room or call 911.

Cialis (tadalafil)

By: Medically reviewed by Dena Westphalen, Pharm.D. on May 15, 2020 — Written by Jennifer Mitri Williamson, Pharm.D.
Source: Medical News Today
web site: https://www.medicalnewstoday.com/articles/cialis

What is Cialis?

Cialis is a brand-name prescription medication. It’s FDA-approved to treat the following in men:

erectile dysfunction (ED), a condition in which you can’t get or keep an erection
symptoms of benign prostatic hyperplasia (BPH), a prostate condition that may cause problems with urination
ED and symptoms of BPH together

Cialis comes as a tablet that you swallow. It’s available in four strengths: 2.5 mg, 5 mg, 10 mg, 20 mg. Depending on your situation and what condition Cialis is treating, you’ll take the drug either before sexual activity or once a day.

Cialis contains the active drug ingredient tadalafil and belongs to a group of medications called phosphodiesterase 5 (PDE5) inhibitors. For ED, Cialis relaxes the blood vessels leading to the penis so that more blood can flow into it. For BPH symptoms, Cialis relaxes muscles in your bladder, allowing you to urinate more easily.

Cialis is available only by prescription. It’s not available over the counter.
Effectiveness

For information on the effectiveness of Cialis in treating these conditions, please see the “Cialis uses” section below.25
Cialis generic

Cialis is available as a generic drug called tadalafil. A generic drug is an exact copy of the active drug in a brand-name medication. The generic is considered to be as safe and effective as the original drug. Generics tend to cost less than brand-name drugs.

In some cases, the brand-name drug and the generic version may come in different forms and strengths.
Cialis dosage

The Cialis dosage your doctor prescribes will depend on several factors. These include:

the type and severity of the condition you’re using Cialis to treat
your age
other medical conditions you may have
how often you’re taking Cialis

Typically, your doctor will start you on a low dosage. Then they’ll adjust it over time to reach the amount that’s right for you. Your doctor will ultimately prescribe the smallest dosage that provides the desired effect.

If you have certain conditions, such as kidney or liver problems, your doctor may have you start with a low dose of Cialis. This is done so that the medication doesn’t affect your other conditions.

The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.
Drug forms and strengths: 2.5 mg, 5 mg, 10 mg, 20 mg

Cialis comes as a tablet that you swallow. It’s available in four strengths: 2.5 mg, 5 mg, 10 mg, and 20 mg.
Dosage for benign prostatic hyperplasia (BPH)

For symptoms of benign prostatic hyperplasia, the recommended dosage of Cialis is 5 mg once a day. You should take the drug at about the same time each day.

In some cases, your doctor may have you take 5 mg of Cialis a day along with finasteride (Proscar) to treat BPH. (See the “Cialis use with other drugs” section below to learn more.) If you take both Cialis and finasteride, you’ll usually take these two drugs for up to 26 weeks.
Dosage for erectile dysfunction (ED)

Here’s some information on the Cialis dosages for erectile dysfunction.
Cialis taken as needed

If your doctor recommends that you take Cialis only as needed for ED, the usual dosage is 10 mg before sexual activity. They may reduce this to 5 mg if the medication is working too well. But if this dose doesn’t work for you, your doctor may have you take two 5 mg tablets of Cialis at once. This will increase the dose back to 10 mg.

If the 10-mg dose of Cialis isn’t working well enough, your doctor may increase it to 20 mg. The maximum dose of Cialis that can be taken in a day is 20 mg.

You shouldn’t take Cialis more than once a day. In clinical trials, Cialis helped people with ED symptoms for up to 36 hours after their dose. So if you’re taking the medication only as needed, you shouldn’t have to take it every day.

Note: It’s very important that you take only the amount of Cialis that your doctor instructs you to take. And be sure to speak with them if you feel you need more of the drug, rather than increasing your dosage yourself.
Cialis taken once a day

Cialis can also be taken once a day to treat ED. In this case, the dosage usually starts at 2.5 mg a day. If this daily dosage doesn’t work well enough to treat your ED, your doctor may increase it to 5 mg a day.

And if your doctor recommends using Cialis every day, you should take the drug at about the same time each day. You don’t need to take Cialis before sexual activity unless your doctor says to use the drug only as needed. (See the “Cialis taken as needed” section right above to learn more.)

Note: It’s very important that you take only the amount of Cialis that your doctor instructs you to take. And be sure to speak with them if you feel you need more of the drug, rather than increasing your dosage yourself.
Dosage for ED and BPH

To treat both ED and symptoms of BPH together, the typical dose of Cialis is 5 mg, once a day. You should try to take your dose at about the same time each day.
Higher dosages of Cialis

The approved dosages of Cialis for ED, BPH symptoms, or both, are between 2.5 mg and 20 mg a day or as needed. Dosages higher than 20 mg a day haven’t been studied, and it’s not known what side effects may occur with them.

For example, if you take your “as-needed” dose of 20 mg twice a day, you’ll end up taking 40 mg. This dose is too high and may cause serious side effects, such as decreased blood pressure.

Note: It’s very important that you take only the amount of Cialis that your doctor instructs you to take. And be sure to speak with them if you feel you need more of the drug, rather than increasing your dosage yourself.

Does drinking water improve erectile dysfunction?

By: Medically reviewed by Daniel Murrell, MD on May 14, 2018 — Written by Rachel Nall, RN, MSN, CRNA
Source: Medical News Today
web site: https://www.medicalnewstoday.com/articles/321795

Erectile dysfunction can be affected by many factors, including hydration levels. Dehydration can reduce blood volume and affect mood, so a person may find that drinking water can help with maintaining an erection.

Erectile dysfunction, or ED, is when a man has difficulty achieving or maintaining an erection. An estimated 30 million men experience ED at some point. A wide range of factors can influence ED.

In this article, we look at the relationship between hydration and both ED and sex drive, how you can tell if you are dehydrated, and other causes of erectile dysfunction.
Is dehydration linked to ED?23
Being dehydrated may cause a number of physiological changes, such as temporary ED.

It is possible for a person’s hydration levels to influence temporary ED. A lack of sufficient body water can affect a person physiologically and mentally.

Several elements are needed for a man to achieve and maintain an erection. A breakdown in one or more of these steps means he may not be able to achieve an erection that is firm enough for sex. The process includes:

sexual arousal, or the messages sent to the brain that stimulate blood flow to the penis
increased blood flow into two chambers in the penis called the corpus cavernosum that leads to the penis swelling and becoming erect
when a man achieves ejaculation, the blood leaves the chambers, and the erection goes away

When a man is dehydrated, he does not have as much blood volume in his body as when he is properly hydrated. Therefore, his blood vessels become constricted, as there is not enough blood to keep them tense. This impairs blood flow to all parts of the body, including the penis.

Little research has looked at whether dehydration directly causes erectile dysfunction, so further studies are needed.

When a person is dehydrated, their body releases greater amounts of the enzyme angiotensin I, which leads to the blood vessels constricting.

The presence of angiotensin II, which the body makes from angiotensin I, has been associated with sexual dysfunction in animal studies, although more research is needed into how this affects humans.

In addition to the physical effects of dehydration that impact penile erection, mood is also associated with dehydration.

A small scale 2011 study found that mild dehydration was associated with impaired memory, tension, and anxiety in men.

A person’s mental state can have a profound effect on their sex drive and ED. According to the American Academy of Family Physicians, stress, anxiety, depression, and nervousness can all contribute to ED. Therefore, it is possible that the mood changes associated with dehydration could lead to ED.

What effect does ADHD have on sexuality?

By: Medically reviewed by Timothy J. Legg, PhD, PsyD on May 19, 2018 — Written by Jon Johnson
Source: Medical News Today
web site: https://www.medicalnewstoday.com/articles/321860#how-does-adhd-impact-sexuality-

Attention deficit hyperactivity disorder (ADHD) causes a range of symptoms, including hyperactivity, difficulty paying attention, and behavioral problems. ADHD may also affect romantic relationships, feelings of self-worth, or even the ability to perform sexually.

These markers are not used to make a diagnosis, and they may be due to the disorder itself or develop as a side effect of medicines used for treatment.

Though ADHD is frequently diagnosed in childhood, it affects the lives of many adults. Some adults with ADHD report experiencing changes in their sex life.
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How does ADHD impact sexuality?

Nailing down symptoms is difficult because these changes can affect everyone differently:
Hyposexuality
A person with ADHD may have a low sex drive.

Some people with ADHD report changes in their sex drive.

Some experience hyposexuality or the loss of the desire for sex.

A person experiencing hyposexuality may have no interest in sexual activity whatsoever.

They may find sex challenging to focus on, lose interest in the middle of sexual activity, or become easily distracted.

Hyposexuality might be symptomatic of ADHD in some cases, but it is also a possible side effect of some ADHD medications or antidepressants that are often used to treat ADHD symptoms.
Inability to orgasm

Many people with ADHD experience other issues apart from their sex drive. Some people may have a healthy sex drive but have difficulties reaching orgasm, even after prolonged stimulation. This may be due to boredom, problems staying focused, or other feelings. In some cases, an inability to orgasm is a side effect of medications.
Hypersensitivity

Many people with ADHD experience a physical hypersensitivity to a variety of things, including touch.

Being hypersensitive may mean that stimulation of their genitals might be uncomfortable or even painful in someone with ADHD. This sensitivity may also extend to other senses as well.

Smells or tastes associated with sex may reduce arousal or make it difficult for a person to focus on the act itself, which may lead to difficulties in staying aroused.
Hyperactivity

Hyperactivity, which is a symptom closely associated with ADHD, might also affect a person’s sex life. People with ADHD may find it difficult to relax or unwind, which could make it hard for them to become aroused. They may also feel the need to switch positions frequently or may be unable to stay focused long enough to have sex.
Other symptoms

Adults with ADHD may also present with a range of other symptoms that may include emotional instability or symptoms of anxiety and depression. Symptoms such as these can be extremely challenging on a day-to-day basis and may also affect a person’s sex life.

These emotional issues might put stress on a romantic relationship, making a difficult situation even more difficult than before.

These feelings of anxiety and instability may also affect a person with ADHD who is not in a romantic relationship. These emotions might lead to reluctance in seeking healthful relationships with other people or worry surrounding their individual sexuality.

Can stress make you ill?

By: Medically reviewed by Stacy Sampson, DO on March 31, 2020 New — Written by Rachel Nall, RN, MSN, CRNA
Source: Medical News Today
web site: https://www.medicalnewstoday.com/articles/can-stress-make-you-sick#can-it

If a person experiences stress on a regular basis, they might notice symptoms such as irregular eating patterns, difficulty sleeping, or problems with their heart and immune system.

Stress is a natural part of the body’s existence. However, stress is meant to be an occasional emotion, not a constant one.

This article will look at the effects that stress can have on the body, as well as some things a person can do to lower their stress levels.22

tress can trigger a variety of diseases and conditions.

When a person experiences stress, the body increases its production of steroid hormones called glucocorticoids. These include cortisol, which is also known as the “stress hormone.”

Although these hormones typically help regulate the immune system and help reduce inflammation, chronic stress can cause a miscommunication between the immune system and the hypothalamic-pituitary-adrenal axis. This is the interaction between the adrenal glands, the pituitary gland, and the hypothalamus.

As a result, there is a higher chance of developing mental and physical conditions, including:

fatigue
diabetes
obesity
depression
immune conditions

Stress hormones can depress the immune system by lowering the activity of cells that respond to viruses and bacteria or other inflammatory conditions.

The following sections will discuss the physical effects of stress in more detail.

 

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